Thermo Fisher Scientific Caveolin 3 Recombinant Rabbit Monoclonal Antibody (SY22-06)
Caveolin-3 단백질을 표적하는 재조합 토끼 단클론 항체. Western blot 및 IHC(Paraffin)에서 높은 특이성과 재현성을 제공. Lot 간 일관성 우수하며 동물 유래 성분이 없는 포뮬레이션. 연구용으로 근육 및 심근 관련 단백질 연구에 적합.
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- MA532084
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SY22-06 |
| Immunogen | Recombinant protein within Human Caveolin-3 aa 1–125 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809378 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Specific antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
Caveolin-3 (CAV3) acts as a scaffolding protein within caveolar membranes. It interacts with G-protein alpha subunits to regulate their activity and may modulate voltage-gated potassium channels.
Caveolin-3 plays a critical role in sarcolemma repair in skeletal and cardiac muscle, enabling rapid membrane resealing after mechanical stress. It mediates recruitment of CAVIN2 and CAVIN3 to caveolae.
Mutations in CAV3 are associated with conditions such as HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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