Thermo Fisher Scientific Paxillin Recombinant Rabbit Monoclonal Antibody (SY23-02)
Recombinant rabbit monoclonal antibody recognizing Paxillin in human, mouse, and rat. Validated for WB, IHC(P), and ICC/IF. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Suitable for research use only.
- 카탈로그번호
- MA532087
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SY23-02 |
| Immunogen | Synthetic peptide within Human Paxillin (aa 1–59) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809381 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Paxillin is a focal adhesion protein and substrate for tyrosine kinases such as Src, FAK, and p210BRC/ABL. Tyrosine phosphorylation of Paxillin is influenced by cell adhesion changes. It associates with FAK and Crk via its SH2 domain, independent of the extracellular matrix. Originally identified in fibroblasts, Paxillin phosphorylation also plays a role in neurite extension during differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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