Thermo Fisher Scientific Integrin beta 7 Monoclonal Antibody (FIB504), PE, eBioscience

Thermo Fisher Scientific Integrin beta 7 Monoclonal Antibody (FIB504), PE, eBioscience™

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 5 µL (0.125 µg)/test
• Publications: View 5 publications

Product Specifications

Available Formats

• Unconjugated
• Biotin
• FITC
• PE-Cyanine7
• Request custom conjugation

Product Specific Information

The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7, a 130 kD glycoprotein that associates with integrin alpha 4 (CD49d) to form the α4β7 integrin (LPAM-1) and with alpha E (CD103) to form the αEβ7 integrin (HML-1).
These complexes are expressed on intraepithelial lymphocytes and T cells adjacent to mucosal epithelium.
Main ligands include VCAM-1 (CD106), MAdCAM-1, fibronectin, and E-cadherin (CD324).
Integrin β7 mediates leukocyte adhesion and transmigration during inflammation.
The FIB504 antibody has reported blocking activity.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated for human peripheral blood cells

• Recommended use: 5 µL (0.125 µg) per test
• Typical test volume: 100 µL
• Cell count range: 10⁵–10⁸ cells/test

Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered

Target Information

Integrin β7 forms complexes with α4 (CD49d) and αE (CD103), contributing to lymphocyte adhesion and migration.
Ligands: VCAM-1, MAdCAM-1, fibronectin, and E-cadherin.
Plays a key role in leukocyte-endothelial interactions and inflammatory response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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