Thermo Fisher Scientific UBE3A/E6-AP Monoclonal Antibody (PCRP-UBE3A-1A2)
Thermo Fisher Scientific의 UBE3A/E6-AP 단클론 항체(PCRP-UBE3A-1A2)는 인간 UBE3A 단백질을 인식하며 ICC/IF, 유세포분석, 펩타이드 어레이에 적합합니다. 단클론 Mouse IgG1 항체로, Protein A/G 정제 및 PBS 버퍼에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-UBE3A-1A2 |
| Immunogen | Recombinant full-length human UBE3A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
UBE3A (ubiquitin-protein ligase E3A, also known as E6AP) is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 conjugating enzyme to its substrates. Known substrates include ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, PML tumor suppressor, and CDKN1B.
UBE3A may act as a cellular quality control ubiquitin ligase, aiding in degradation of misfolded cytoplasmic proteins and regulating the circadian clock.
Defects in UBE3A are associated with Angelman syndrome (AS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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