Thermo Fisher Scientific UBE3A/E6-AP Monoclonal Antibody (PCRP-UBE3A-1A2)
UBE3A/E6-AP 단백질을 인식하는 Mouse Monoclonal Antibody로, Human 시료에 반응합니다. ICC/IF, Flow Cytometry, Peptide Array 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 보존제가 없습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 7337-MSM2-P1ABX
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-UBE3A-1A2 |
| Immunogen | Recombinant full-length human UBE3A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
UBE3A (ubiquitin-protein ligase E3A, also known as E6AP) is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 conjugating enzyme to its substrates. Known substrates include ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, PML tumor suppressor, and CDKN1B.
UBE3A functions in protein quality control by promoting degradation of misfolded cytoplasmic proteins and plays a role in circadian clock regulation.
Defects in UBE3A are associated with Angelman syndrome (AS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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