Thermo Fisher Scientific Phospho-NFATC3 (Ser165) Polyclonal Antibody
NFATC3 단백질의 Ser165 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 ICC/IF에 적합하며, 인간·마우스·랫트 반응성. 고순도 정제, 액상 형태로 제공되며 -20°C 보관.
- 카탈로그번호
- PA5104980
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFATC3 (Accession Q12968), corresponding to amino acid residues around phosphorylated Ser165 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816453 |
Product Specific Information
Antibody detects endogenous levels of NFAT4 only when phosphorylated at Serine 165.
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
Use of multiple polyadenylation sites has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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