Thermo Fisher Scientific Phospho-IKK beta (Ser476) Polyclonal Antibody
Phospho-IKK beta (Ser476)에 특이적인 Rabbit Polyclonal Antibody로, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human 시료에 반응하며, Protein A로 정제된 액상 형태. NF-κB 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Ser476 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Phosphorylation of serine residues on I-kappa-B proteins by IKK kinases, including IKBKB, marks them for degradation via the ubiquitination pathway, enabling activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-kappa-B signaling, activated by stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or cellular stress.
It functions within the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on key serine residues, leading to their polyubiquitination and proteasomal degradation.
This process releases NF-kappa-B to translocate into the nucleus and activate transcription of genes involved in immune response, cell growth, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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