Thermo Fisher Scientific Phospho-IKK beta (Ser474) Polyclonal Antibody
인간 IKK beta의 Ser474 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, NF-κB 신호전달 연구에 적합합니다. IHC, ICC, ELISA 등 다양한 응용 가능하며, 고순도 Protein A 정제 및 안정적 보관용 버퍼 제공.
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Thermo Fisher Scientific Phospho-IKK beta (Ser474) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Ser474 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Phosphorylation of serine residues on I-kappa-B proteins by IKK kinases, including IKBKB, targets them for degradation via the ubiquitination pathway, enabling activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-kappa-B signaling, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other cellular stresses.
It functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on critical serine residues, leading to their polyubiquitination and proteasomal degradation. This process releases NF-kappa-B, which translocates to the nucleus to activate transcription of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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