Thermo Fisher Scientific S100B Recombinant Superclonal Antibody (16HCLC)
Recombinant Superclonal™ rabbit antibody recognizing human, mouse, and rat S100B. High sensitivity and reproducibility for WB, IHC, and ICC. Liquid form, 0.5 mg/mL, Protein A purified, suitable for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 16HCLC |
| Immunogen | Peptide corresponding to amino acids 18–40 of human S100B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532695 |
Product Specific Information
This antibody is predicted to react with rat, non-human primate, and rabbit based on sequence homology.
Recombinant rabbit Superclonal™ antibodies are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies. Each lot is produced with a defined mixture of light and heavy chains, eliminating biological variability.
Formerly known as “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.
Target Information
S100B belongs to the S100 family of calcium-binding proteins with two EF-hand motifs. These proteins are found in the cytoplasm and/or nucleus of various cells and regulate processes such as cell cycle progression and differentiation.
S100B functions include neurite extension, melanoma cell proliferation, Ca²⁺ flux regulation, inhibition of PKC-mediated phosphorylation, astrocytosis, axonal proliferation, and inhibition of microtubule assembly.
Altered expression or chromosomal rearrangements of S100B have been linked to diseases including Alzheimer’s disease, Down’s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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