Thermo Fisher Scientific Phospho-p70 S6 Kinase (Thr444) Polyclonal Antibody
p70 S6 Kinase의 Thr444 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. 세포 성장 및 단백질 합성 경로 연구에 활용 가능. -20°C 보관, wet ice 배송.
- 카탈로그번호
- PA5104845
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RPS6KB1 (Accession P23443), corresponding to amino acid residues around phosphorylated Thr444. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816318 |
Product Specific Information
This antibody detects endogenous levels of p70 S6 Kinase only when phosphorylated at Thr444, a site historically referenced as Thr421.
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase containing two non-identical catalytic domains that phosphorylate several residues of the S6 ribosomal protein. It is predominantly localized in the cytoplasm and plays a key role in growth factor-regulated cell proliferation, cell motility, immune response, and tissue repair. Acting downstream of phosphoinositide (PI) 3-kinase, its main physiological target is the S6 ribosomal protein, which promotes protein synthesis. Amplification and overexpression of p70 S6 kinase are observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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