Thermo Fisher Scientific Phospho-GATA3 (Ser308) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of GATA3 only when phosphorylated at Serine 308.

Target Information

The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 has been shown to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA is expressed in T cells but not in B cells or macrophages. It is abundantly expressed in the T-lymphocyte lineage and participates in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene, which comprises six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by separate exons highly conserved with those of GATA1, but no other structural homologies were found.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.