Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI4D8), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The SF3A1 gene encodes subunit 1 of the splicing factor 3a complex, which includes subunits 1, 2, and 3. This complex is essential for converting 15S U2 snRNP into an active 17S particle that mediates pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, characterized by SURP motifs involved in RNA binding. It contains tandem SURP motifs in the N-terminal region and a proline-rich plus ubiquitin-like domain in the C-terminal region.
Binding studies indicate that SURP motifs are required for interaction with subunit 3, while subunit 2 may bind via sequences C-terminal to these motifs.
Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.