Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI2C4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The SF3A1 gene encodes subunit 1 of the splicing factor 3a protein complex. This complex includes subunits 1, 2, and 3, and is essential for converting 15S U2 snRNP into the active 17S particle that mediates pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, characterized by SURP motifs involved in RNA binding. The N-terminal region contains tandem SURP motifs, while the C-terminal region includes a proline-rich domain and a ubiquitin-like domain.
Binding studies indicate that SURP motifs are required for interaction with subunit 3, while sequences C-terminal to these motifs may interact with subunit 2.
Alternative splicing generates multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.