Thermo Fisher Scientific Amyloid Precursor Protein Monoclonal Antibody (3E9)
Alzheimer 연구용 Amyloid Precursor Protein(β-APP) 검출용 mouse monoclonal antibody. Western blot, IHC, ICC 등 다양한 응용 가능. Human 및 mouse 반응성. Unconjugated, Protein A 정제, 1 mg/mL 농도.
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Applications 및 Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 5–10 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 1:200 | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E9 |
| Immunogen | Synthetic peptide corresponding to residues L(18) E V P T D G N A G L L A E P Q I A M F C(38) of human Amyloid Precursor Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% sucrose |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779259 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.
Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (βAPP) through a two-step proteolytic process involving β-secretase (BACE) and γ-secretase.
The cleavage by BACE releases a soluble fragment and leaves a membrane-bound remnant, which is further processed by γ-secretase to produce amyloid beta peptide.
γ-secretase is a multi-subunit complex containing presenilin-1 and -2, and associated with nicastrin, which modulates Abeta production.
Abeta forms extracellular filamentous deposits found in amyloid plaques and neurofibrillary tangles, characteristic of Alzheimer’s disease and other amyloid-related disorders such as Lewy body dementia, Down’s syndrome, and cerebral amyloid angiopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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