Thermo Fisher Scientific beta Amyloid Monoclonal Antibody (2C8)
베타 아밀로이드(Abeta 40/42) 검출용 마우스 단클론 항체로, WB, IHC, ICC/IF에 적합합니다. 알츠하이머 관련 연구에 활용되며, 합성 펩타이드(1-16) 면역원 사용. 비결합형 액상 형태로 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C8 |
| Immunogen | Synthetic peptide corresponding to residues 1–16 of beta Amyloid |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779257 |
Product Specific Information
This antibody reacts with synthetic beta amyloid (Abeta 40 and Abeta 42) in Western blots.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process:
- Beta-secretase (BACE) cleaves the extracellular, amino-terminal domain of beta APP.
- Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, further processes the membrane-bound remnant to generate amyloid beta peptide.
Associated protein components such as nicastrin bind to beta APP and modulate Abeta production.
Abeta is found in amyloid cores, neuritic plaques, and neurofibrillary tangles, commonly linked to Alzheimer’s disease.
Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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