Thermo Fisher Scientific Agrin Monoclonal Antibody (AGR 131)
Agrin 단백질의 N1 isoform을 검출하며 N4는 검출하지 않음. 다양한 스플라이스 변이(X, Y, Z)를 인식. Western blot, IHC, ICC/IF, RIA 등 다양한 응용 가능. 단일클론 마우스 IgG1 항체로 Protein G 정제. 장기 보관 시 -20°C에서 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 |
| Radioimmune Assays (RIA) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AGR 131 |
| Immunogen | Recombinant rat agrin, C-terminal construct |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.2, with 0.1 mM PMSF, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2273821 |
Product Specific Information
This antibody detects all N1 isoforms, but fails to detect the N4 protein. It also detects the X, Y, and Z splice variants.
Target Information
Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in postsynaptic differentiation. It is responsible for clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants arise from alternative mRNA splicing. Splice forms with inserts at two sites in the carboxy terminus designated y and z show high affinity for AChRs, while those lacking these inserts associate weakly. Muscle alpha-dystroglycan may act as the receptor for agrin clustering activity, though this remains debated. Tyrosine phosphorylation is implicated as an early step in AChR aggregation, and the receptor tyrosine kinase MuSK interacts with Agrin and is localized to developing muscle.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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