Thermo Fisher Scientific mGluR1 Polyclonal Antibody
mGluR1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 등 반응. 항원 친화 크로마토그래피로 정제된 액상 형태. 신경계 연구 및 글루타메이트 수용체 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Published Species | Guinea pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide comprising residues 1159–1171 of the human GluR1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4 °C short term; for long-term storage, store at –20 °C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1017267 |
Product Specific Information
- Suggested positive control: human brain lysate, rat dorsal root ganglion, and rat brain (cingulate cortex), antigen standard for GRIN1 (transient overexpression lysate).
- Immunogen sequence: SSVPSSPVSE SVL
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors involved in fast excitatory synaptic transmission.
Metabotropic glutamate receptors (mGluRs) regulate enzymes producing second messengers via G-protein coupling.
Group-I receptors (including mGluR1a and mGluR5) stimulate phospholipase C, increasing phosphoinositide turnover and calcium release.
Group-II (mGluR2, mGluR3) and Group-III receptors inhibit adenylyl cyclase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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