Thermo Fisher Scientific TRPA1 Polyclonal Antibody
TRPA1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫드 등에서 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 냉각 통증 연구 및 TRP 채널 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:250 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | – |
| Immunocytochemistry (ICC/IF) | 1:200 | – |
| Flow Cytometry (Flow) | Assay-Dependent | – |
| ELISA | Assay-Dependent | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Guinea pig, Human, Mouse, Rat, Zebrafish |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus (residues 1–100) of the human TRPA1 protein (Swiss-Prot #O75762) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2209939 |
Product Specific Information
- The target sequence has 69% sequence homology with rat.
- Suggested positive control: human brain membrane fraction.
Target Information
TRPA1 is a TRP-related ion channel that responds to cold temperatures and pungent compounds, playing a role in nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia and is primarily expressed in sensory neurons. Blocking TRPA1 may provide therapeutic potential for treating cold hyperalgesia caused by inflammation and nerve damage. TRPA1 is also expressed outside the CNS and dysregulated during oncogenic transformation. The protein is structurally related to ankyrin and transmembrane proteins, and may function in signal transduction and growth control.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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