Thermo Fisher Scientific c-Myc Monoclonal Antibody (OTI5G3), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with regulation of cell proliferation and cycle control. c-Myc is also essential for vasculogenesis and angiogenesis in tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression can induce apoptosis. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags.

Amplification of the c-Myc gene has been observed in various human tumors, including lung, breast, and colon carcinomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-myc expression occurs in tumors of multiple origins such as colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.