Thermo Fisher Scientific c-Myc Monoclonal Antibody (OTI1A6), TrueMAB
Human c-Myc 단백질을 인식하는 mouse monoclonal antibody로 Western blot, IHC, ICC/IF, Flow cytometry에 적합. TrueMAB 포맷으로 높은 특이성과 재현성 제공. 연구용으로 세포 증식 및 종양 관련 연구에 활용 가능.
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Thermo Fisher Scientific c-Myc Monoclonal Antibody (OTI1A6), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A6 |
| Immunogen | Full-length human recombinant protein of human Myc produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with regulation of cell proliferation and cycle.
Studies indicate c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated c-Myc expression can induce apoptosis and is linked to multiple human cancers including lung, breast, and colon carcinomas.
Translocation of the c-myc locus to immunoglobulin loci is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression occurs across diverse tumor types such as colorectal, gastric, hepatic, ovarian, thyroidal, and hematopoietic neoplasms.
Antibodies against c-Myc epitopes detect Myc-tagged fusion proteins at either amino- or carboxy-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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