Thermo Fisher Scientific Stat4 Monoclonal Antibody (OTI2A2), TrueMAB
Human STAT4 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P) 분석에 적합합니다. Affinity chromatography로 정제된 액상 형태이며, 1 mg/mL 농도. PBS/BSA/glycerol 완충액에 보관하며 -20°C에서 안정적입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:100
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A2 |
| Immunogen | Recombinant fragment expressed in E. coli corresponding to amino acids 633–652 of human Stat4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein shares 52% similarity with STAT1 and 47% with STAT3. Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homo- and heterodimers with related STAT family members.
Tyrosine phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen, and testis.
STAT4 is activated by the cytokine interleukin 12 (IL-12), which induces IFN-gamma production and promotes Th1 cell development essential for defense against intracellular pathogens. STAT4-deficient mice show impaired Th1 development and enhanced Th2 response. Additionally, IFN-α/β activation of STAT4 is required for IFN-γ production during viral infection.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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