Thermo Fisher Scientific c-Myc Monoclonal Antibody (OTI3F2), TrueMAB
c-Myc 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 시료 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. 세포 증식 및 종양 관련 연구용에 적합.
- 카탈로그번호
- TA500003x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific c-Myc Monoclonal Antibody (OTI3F2), TrueMAB
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F2 |
| Immunogen | Full length human recombinant protein of human Myc produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays key roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is functionally associated with cell proliferation and cycle regulation.
Studies indicate that c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc can induce apoptosis in different cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.
Amplification of the c-Myc gene has been found in several human tumors, including lung, breast, and colon carcinomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci (chromosomes 14, 2, or 22) is described in Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant expression of c-Myc occurs in tumors of colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic origins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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