Thermo Fisher Scientific DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein that plays an important role in vascular development.
Functional Application: Blocking.

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a homolog of the Drosophila delta protein and functions as a transmembrane-bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote the formation of a differentiated vascular network.

DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 results in increased vascular proliferation but defective maturation, leading to decreased tumor growth without apparent toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.