Thermo Fisher Scientific DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46)
DLL4 단백질의 세포외 도메인을 인식하는 단클론 항체로, 혈관 발달 및 Notch 신호 연구에 적합. Flow Cytometry 및 Functional Assay에 사용 가능. Human 시료 반응성, Mouse IgG1 아이소타입. PBS 용액 형태, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MHD4-46 |
| Immunogen | Recombinant soluble human DLL4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745584 |
Product Specific Information
This antibody recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein that plays an important role in vascular development.
Functional Application: Blocking.
Target Information
Delta-like ligand 4 (DLL4), also known as Delta-4, is a homolog of the Drosophila delta protein and functions as a transmembrane-bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote the formation of a differentiated vascular network.
DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 results in increased vascular proliferation but defective maturation, leading to decreased tumor growth without apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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