Thermo Fisher Scientific CD117 (c-Kit) Monoclonal Antibody (104D2), eFluor 450, eBioscience
인간 CD117(c-Kit) 단백질을 인식하는 Mouse IgG1 단클론 항체로, eFluor 450 형광체가 결합된 제품입니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 405/445 nm 파장에서 Violet Laser로 검출 가능합니다. 혈액세포 및 줄기세포 연구용으로 적합합니다.
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Thermo Fisher Scientific CD117 (c-Kit) Monoclonal Antibody (104D2), eFluor 450, eBioscience
Applications
- Flow Cytometry (Flow): 5 µL (0.125 µg)/test
View 6 publications - Fluorescence Resonance Energy Transfer (FRET): -
View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 450 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 104D2 |
| Conjugate | eFluor™ 450 |
| Excitation / Emission Max | 405 / 445 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_11042291 |
Additional Formats
- APC
- APC-eFluor 780
- FITC
- PE
- PE-Cyanine5
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 702
- Request custom conjugation
Product Specific Information
The 104D2 monoclonal antibody reacts with human CD117 (c-Kit), also known as Steel factor receptor and stem cell factor receptor. CD117 is a 145 kDa tyrosine kinase receptor expressed by hematopoietic progenitor cell subsets and mast cells. Interaction with Steel factor promotes proliferation and differentiation of hematopoietic progenitor cells and mast cell maturation. It is also expressed by melanocytes and plays a role in their activation.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested with normal human peripheral blood cells, usable at 5 µL (0.125 µg)/test. A test corresponds to staining a sample in 100 µL final volume (10^5–10^8 cells/test).
eFluor® 450 is an alternative to Pacific Blue®, emitting at 445 nm and excited at 405 nm (Violet Laser). Ensure instrument compatibility.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
KIT (c-KIT) is a proto-oncogene encoding a type 3 transmembrane receptor for mast cell growth factor (MGF or stem cell factor). KIT regulates growth and activation of various hematopoietic and non-hematopoietic cells. Mutations in KIT are linked to gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Activation of c-Kit triggers autophosphorylation and downstream signaling via Ras/ERK, PI3K, PLC-γ, and JAK/STAT pathways, essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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