Thermo Fisher Scientific Human VGF Synthetic Peptide

Thermo Fisher Scientific Human VGF Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human VGF.
PEP-0643 can be used as a blocking peptide with polyclonal antibody PA5-20523.

Target Information

VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells.
This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells.
VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas.
Recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.