Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI3C1), TrueMAB
USP7 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Human 시료 반응성이 있으며, HEK293T 세포에서 발현된 full-length recombinant 단백질로부터 제작되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C1 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.79 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from its substrates. This deubiquitylating activity stabilizes substrate proteins by preventing their degradation. USP7 is known to antagonize Mdm2, an E3 ubiquitin ligase that targets the tumor suppressor protein p53 for degradation. By deubiquitinating p53, USP7 can stabilize and protect it from Mdm2-mediated degradation, suggesting a potential tumor suppressor role. Additionally, USP7 may also play a role in oncogenic pathways involving p53 activation through ARF-dependent or independent mechanisms, providing an alternative cellular defense against oncogenic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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