Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI3D3), TrueMAB
USP7 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 단백질을 항원으로 제작되었으며, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D3 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrates. It stabilizes proteins by preventing their degradation via the ubiquitin-proteasome pathway. USP7 antagonizes Mdm2, thereby stabilizing the tumor suppressor p53. Under oncogenic stress, USP7 can deubiquitinate and protect p53 from Mdm2-mediated degradation, suggesting a tumor-suppressive role. Additionally, USP7 may provide an alternative mechanism for p53 activation independent of ARF, helping cells respond to oncogenic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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