Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI3D5), TrueMAB
USP7 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다. p53 및 Mdm2 관련 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D5 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.64 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins. This activity stabilizes proteins by preventing their degradation. USP7 is a known antagonist of Mdm2, the E3 ubiquitin ligase that targets p53 for degradation. By deubiquitinating p53, USP7 can stabilize p53 and contribute to tumor suppression in response to cellular stress. Additionally, USP7 may play a role in oncogenic signaling pathways involving Myc and E1A, potentially offering an alternative mechanism for p53 stabilization independent of ARF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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