Thermo Fisher Scientific Phospho-Tau (Ser739) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

Antibody detects endogenous levels of Tau only when phosphorylated at Ser739, which site historically referenced as Ser422.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Axonal polarity is predetermined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome.
Short isoforms allow cytoskeletal plasticity, while longer isoforms may play a role in stabilization.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), building blocks of neurofibrillary lesions in Alzheimer’s disease brain.
Hyper-phosphorylation impairs Tau’s microtubule binding, destabilizing microtubules and leading to neuronal degeneration.
Numerous serine/threonine kinases phosphorylate Tau, including GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is found in neurofibrillary lesions in Alzheimer’s disease and other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.