Thermo Fisher Scientific NCoR1 Polyclonal Antibody
Thermo Fisher Scientific의 NCoR1 폴리클로날 항체로, 인간 및 마우스 N-CoR 단백질을 검출합니다. Western blot, IHC, ICC/IF, ChIP 등에 적합하며 고순도 항원 친화 크로마토그래피로 정제되었습니다. PBS/BSA 버퍼에 보존되며 -20°C에서 안정적으로 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 10 publications |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | View 1 publication |
| ELISA | - | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| ChIP assay (ChIP) | Assay-dependent | View 9 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C P(2427) A P L L S A Q Y E T L S D S D D(2443) of mouse N-CoR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2149004 |
Product Specific Information
PA1-844A detects human and mouse nuclear receptor corepressor (N-CoR).
It has been successfully used in Western blot, ICC/IF, IHC (P), and ChIP procedures.
By Western blot, this antibody detects a ~270 kDa protein representing N-CoR from HeLa cell extracts and mouse RAW 264.7/primary macrophages.
Not recommended for mouse C2C12 cells in immunofluorescent applications.
The immunogen is a synthetic peptide corresponding to residues C P(2427) A P L L S A Q Y E T L S D S D D(2443) of mouse N-CoR.
This immunizing peptide (Cat. # PEP-061) is available for neutralization and control experiments.
Target Information
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery.
It is part of a complex including histone deacetylases and transcriptional regulators similar to yeast Sin3p.
Located between Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17.
Alternate splicing results in multiple transcript variants. Pseudogenes are found on chromosomes 17 and 20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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