Thermo Fisher Scientific PGP9.5 (soluble) Polyclonal Antibody
Thermo Fisher Scientific의 PGP9.5 (soluble) 다클론 항체는 인간 PGP9.5 단백질을 인식하며, 신경세포 및 신경섬유 연구에 적합합니다. IHC(F) 및 ICC/IF에서 사용 가능하며, 원숭이와 교차 반응이 예상됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA124674
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues G(175)ASSEDTLLKDAAKVCR(191) of soluble, cytoplasmic, human PGP9.5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_795252 |
Product Specific Information
PA1-24674 is expected to cross react with Macaque monkey (87% conserved) due to sequence homology.
Target Information
PGP9.5 (Protein Gene Product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and was first identified by high-resolution two-dimensional PAGE.
PGP9.5 is a member of the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) and possesses both hydrolase and ligase activities, generating ubiquitin monomers from small C-terminal adducts.
PGP9.5 is found in:
- Neurons and nerve fibers throughout the central and peripheral nervous systems
- Neuroendocrine cells
- Renal tubules
- Spermatogonia and Leydig cells of the testis
- Ova and corpus luteum cells
Overexpression of PGP9.5 is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases.
It serves as a useful neuronal marker and is valuable in studies of neurodegenerative disorders such as Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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