Thermo Fisher Scientific CCL3 Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

Mouse MIP-1α was tested for its ability to neutralize the bioactivity of recombinant mouse MIP-1α in a cell proliferation assay using hematopoietic stem cells.
The ND50 of the antibody is defined as the concentration of antibody resulting in a one-half maximal inhibition of bioactivity of recombinant mouse MIP-1α, which is present at five times its own EC50 (the concentration of recombinant mouse MIP-1α producing a one-half maximal bioactivity without antibody).

Target Information

MIP-1α and MIP-1β are structurally and functionally related CC chemokines.
They participate in host response to bacterial, viral, parasitic, and fungal pathogens by regulating the trafficking and activation state of inflammatory cells such as macrophages, lymphocytes, and NK cells.
While both exert similar effects on monocytes, MIP-1α selectively attracts CD8+ lymphocytes, and MIP-1β selectively attracts CD4+ lymphocytes.
Additionally, both are potent chemoattractants for B cells, eosinophils, and dendritic cells.
Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.