Thermo Fisher Scientific Phospho-MCM3 (Ser160) Polyclonal Antibody
MCM3 단백질의 Ser160 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 고순도 크로마토그래피 정제, PBS/glycerol 버퍼 보존. 인간, 생쥐, 랫트 반응성.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MCM3 (Accession P25205), corresponding to amino acid residues around phosphorylated Ser160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816972 |
Product Specific Information
This antibody detects endogenous levels of MCM3 only when phosphorylated at Ser160.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may participate in the formation of replication forks and recruitment of other DNA replication-related proteins.
MCM3 is a subunit of the MCM2–7 complex and interacts directly with MCM5/CDC46. It also interacts with MCM3AP, a chromatin-associated acetyltransferase, which acetylates MCM3 and inhibits DNA replication initiation and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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