Thermo Fisher Scientific Phospho-CDK1 (Tyr15) Polyclonal Antibody
CDK1의 Tyr15 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 immunocytochemistry에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태로 제공되며, -20°C에서 보관.
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- PA5105543
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK1 (Accession P06493), corresponding to amino acid residues around phosphorylated Tyr15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816971 |
Product Specific Information
This antibody detects endogenous levels of CDK1/CDC2 only when phosphorylated at Tyr15.
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis.
It is a catalytic subunit of the M-Phase Promoting Factor complex that induces entry into mitosis and is conserved among eukaryotes.
Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays apoptosis onset.
Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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