Thermo Fisher Scientific CD41 Monoclonal Antibody (MEM-06), FITC
인간 CD41(GPIIb)을 인식하는 Mouse monoclonal antibody (Clone MEM-06). FITC 형광 표지로 Flow cytometry에 적합. 혈소판 및 거핵세포 표지에 사용. 4°C 보관, 동결 금지. 연구용으로만 사용.
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Applications and Tested Dilution
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-06 |
| Immunogen | Leucocytes from a patient suffering from a LGL type leukaemia |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075439 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- Biotin
- PE
- PerCP
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains: GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa).
CD41 is mainly expressed on platelets and megakaryocytes.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits — 120 kDa alpha and 23 kDa beta — that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor.
CD41 is involved in blood coagulation by mediating platelet aggregation and binds to proteins such as von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury.
It is mainly expressed on the megakaryocyte–platelet lineage and is among the antigens expressed during early hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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