Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (UMAB185), UltraMAB
GEMIN8 단백질을 인식하는 UMAB185 클론의 Mouse Monoclonal Antibody로, Western Blot, IHC, ChIP 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공되며, 연구용으로만 사용.
- 카탈로그번호
- UM800077CF
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:400 | - |
| ChIP assay (ChIP) | Assay-dependent | - |
| Peptide Array (Array) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB185 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The SMN complex plays a catalytic role in assembling small nuclear ribonucleoproteins (snRNPs), fundamental components of the spliceosome. It is crucial for pre-mRNA splicing.
Most spliceosomal snRNPs contain Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) forming a heptameric ring on the small nuclear RNA.
In the cytosol, Sm proteins are initially trapped in an inactive 6S pICln-Sm complex by chaperone CLNS1A. The SMN complex dissociates CLNS1A and facilitates Sm protein transfer to the SMN-Sm complex, triggering core snRNP assembly and nuclear transport.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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