Thermo Fisher Scientific CDH1 Monoclonal Antibody (UMAB184), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. This calcium-dependent cell–cell adhesion glycoprotein consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene are linked to various cancers, including gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to cancer progression by enhancing proliferation, invasion, and metastasis.
The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is essential for internalization. E-cadherin plays a crucial role in tissue architecture and integrity maintenance. In humans, it is encoded by the CDH1 gene located on chromosome 16. Reduced or lost E-cadherin expression is associated with increased tumor invasion and metastasis potential.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.