Thermo Fisher Scientific CD74 Monoclonal Antibody (6D9), PerCP

Applications and Tested Dilution

Product Specifications

Additional Formats

• APC
• FITC
• Request custom conjugation

Product Specific Information

• Overlaps 100% with all 3 isoforms.
• A 1:1,000 dilution of MA5-45386 was sufficient for detection of CD74 in 15 µg of B-Cell Lymphoma cell line Raji by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.
• Detects approximately 33 kDa protein.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains five exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA lacks polymorphisms in the peptide-binding region and serves as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains polymorphisms that determine peptide-binding specificities. Numerous DRB1 alleles have been identified and are used for transplantation typing.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The DR, DQ, and DP loci encode the major expressed products of the human class II region, which bind intracellularly processed peptides, present them to T-helper cells, and play a key role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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