Thermo Fisher Scientific CD74 Monoclonal Antibody (6D9), FITC
CD74 단백질을 검출하기 위한 FITC 결합 마우스 단클론 항체로, 인간 시료에 반응합니다. Western blot 및 면역세포화학(ICC/IF)에 적합하며, 형광 최대값은 498/517 nm입니다. 단백질 G로 정제된 액상 형태로, 4°C 암소 보관이 필요합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD74 Monoclonal Antibody (6D9), FITC
Thermo Fisher Scientific CD74 Monoclonal Antibody (6D9), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D9 |
| Immunogen | Synthetic peptide corresponding to the N-terminal (1–100 aa) of human CD74 conjugated to KLH |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931839 |
Additional Formats
- APC (Cat. MA5-45384)
- PerCP (Cat. MA5-45386)
- Request custom conjugation available
Product Specific Information
- Overlaps 100% with all 3 isoforms of CD74.
- A 1:1,000 dilution of MA5-45385 was sufficient for detection of CD74 in 15 µg of B-Cell Lymphoma cell line Raji by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.
- Detects approximately 33 kDa protein.
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode extracellular domains, exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, while the beta chain contains polymorphisms specifying peptide binding specificities.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
The human MHC class II molecules (DR, DQ, and DP) bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.