Thermo Fisher Scientific Phospho-p38 MAPK alpha (Tyr182) Polyclonal Antibody
p38 MAPK alpha의 Tyr182 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로 -20°C 보관.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAPK14 (Accession Q16539), corresponding to amino acid residues around phosphorylated Tyr182 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816479 |
Product Specific Information
This antibody detects endogenous levels of p38 MAPK only when phosphorylated at Tyrosine 182.
Target Information
MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates cellular responses to stress, inflammation, and other signals. It is inactive in the nonphosphorylated form and becomes activated by dual phosphorylation at Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK differing in tissue expression and affinity for upstream activators and downstream effectors. Upon stimulation by TNF, IL-1, heat shock, or other signals, MAPK kinase-3/6 phosphorylate Thr180 and Tyr182 residues in p38 MAPK. Activated phospho-p38 MAPK phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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