Thermo Fisher Scientific Phospho-LKB1 (Thr189) Polyclonal Antibody
LKB1 단백질의 Thr189 위치 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 Immunocytochemistry에 적합하며, 인체 및 마우스 시료 반응. 고순도 정제, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-LKB1 (Thr189) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STK11 (Accession Q15831), corresponding to amino acid residues around phosphorylated Thr189 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816478 |
Product Specific Information
Antibody detects endogenous levels of LKB1 only when phosphorylated at Threonine 189.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11) is a member of the serine/threonine kinase family and functions as a tumor suppressor.
It physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
LKB1 is localized in both the cytoplasm and nucleus and translocates to mitochondria during apoptosis.
Acts as a master upstream kinase regulating AMPK and AMPK-related kinases.
Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-105005_LKB1_Q15831-1_Rabbit_PDP.jpeg, PA5-105005_LKB1_Q15831-1_Rabbit.svg)
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