Thermo Fisher Scientific TP53BP1 Monoclonal Antibody (OTI6D9), TrueMAB
TP53BP1 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, Lyophilized 형태로 제공. DNA 손상 반응 및 종양 억제 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–300 of human TP53BP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and acts as a substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to sites of double-strand breaks. It participates in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and contributes to DNA repair and genomic stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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