Thermo Fisher Scientific CD105 (Endoglin) Monoclonal Antibody (MEM-229), Biotin
CD105(Endoglin)을 인식하는 Biotin 결합 단일클론 항체로, 인간 및 돼지 시료에 반응합니다. Western blot, IHC(F), ICC/IF, Flow Cytometry 등에 사용 가능하며, 액상 형태로 제공됩니다. 4°C 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-229 |
| Immunogen | Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745504 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow, and erythroid precursors in fetal and adult bone marrow. It is also present on syncytiotrophoblasts in the placenta throughout pregnancy.
Target Information
CD105 (Endoglin) is a type I transmembrane protein highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Upregulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting its role as a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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