Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI3A9), TrueMAB
인간 PELI1 단백질(아미노산 1-245)에 특이적인 Mouse IgG1 단일클론 항체입니다. Western blot에 적합하며, 무보존제 동결건조 형태로 제공됩니다. 연구용으로만 사용되며, Toll-like receptor 경로 연구에 유용합니다.
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Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI3A9), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–245 of human PELI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Pellino proteins are a family of E3 ubiquitin ligases acting as upstream mediators in Toll-like receptor (TLR) pathways, leading to MAP kinase and transcription factor activation.
Pellino 1 is essential for interleukin-1-mediated signaling via interaction with the IRAK4–IRAK–TRAF6 complex, resulting in NF-κB activation.
As an E3 ubiquitin ligase, Pellino 1 catalyzes polyubiquitination of IRAK1 and is activated by phosphorylation from IRAK1, IRAK4, or IKK-related kinases (IKK-ε, TBK1).
Its activity is further modulated by ubiquitination and sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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