Thermo Fisher Scientific TRPM8 Polyclonal Antibody
TRPM8 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 실험에 적합합니다. 인간, 마우스, 랫 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉감 수용체 연구 및 전립선암 관련 연구에 유용합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Guinea pig, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from internal region of human TRPM8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551639 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Marmoset, Mouse, Rat, Guinea pig (100%).
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, being activated by cold temperatures below 25°C. It responds to icilin, eucalyptol, menthol, and changes in intracellular pH. TRPM8 is permeable to monovalent cations (Na⁺, K⁺, Cs⁺) and divalent cation (Ca²⁺).
Expression is mainly restricted to prostate epithelial cells, with moderate mRNA levels in normal prostate tissue and elevated expression in prostate cancer. TRPM8 mRNA is also found in several nonprostatic tumors (breast, colon, lung, skin), but rarely in corresponding normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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