Thermo Fisher Scientific MRP5 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal MRP5 항체로 Western blot에 적합. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. PBS/glycerol buffer에 보관되며 장기 보관 시 -20°C 권장. ABC 수송체 단백질 연구에 적합.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human MRP5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720416 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The MRP5 (Multidrug Resistance-associated Protein 5) is a member of the ATP-binding cassette (ABC) transporter superfamily. These proteins transport various molecules across cellular membranes and are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
MRP5 is part of the MRP subfamily involved in multidrug resistance and functions in the cellular export of cyclic nucleotides. This export contributes to phosphodiesterase degradation and may serve as an elimination pathway for cyclic nucleotides. MRP5 confers resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may play a role in thiopurine resistance in acute lymphoblastic leukemia and resistance to antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected, though the complete sequence and translation initiation site remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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