Thermo Fisher Scientific Kir2.1 (KCNJ2) Monoclonal Antibody (S112), PerCP
Kir2.1(KCNJ2) 단백질을 인식하는 PerCP 결합 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합. 인간, 마우스, 설치류 등에서 반응하며 보존성 높음. 단백질 G 정제, 4°C 보관.
- 판매단위
- pk
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Thermo Fisher Scientific Kir2.1 (KCNJ2) Monoclonal Antibody (S112), PerCP
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S112 |
| Immunogen | Fusion protein amino acids 41–64 and 189–428 of mouse Kir2.1 |
| Conjugate | PerCP |
| Excitation/Emission Max | 482/675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931871 |
Available Formats
Product Specific Information
1 µg/mL of MA5-45417 was sufficient for detection of Kir2.1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 45 kDa. No cross-reactivity against Kir2.2 or Kir2.3.
Target Information
The KIR2 subunit family includes 2.1, 2.2, 2.3, and 2.4.
Unlike G protein-coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity.
KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission.
In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells.
In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule.
KIR2.1, 2.2, and 2.3 associate with the membrane-associated guanylate kinase synapse-associated protein 97 in the cerebellum and heart.
Phosphorylation of KIR2.2 by protein kinase A inhibits the association with SAP97.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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