Thermo Fisher Scientific SCN9A Monoclonal Antibody (N68/6), APC

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated (MA5-27664)
• FITC (MA5-45420)
• PE (MA5-45422)
• PerCP (MA5-45421)
• Custom conjugation available upon request

Product Specific Information

1 µg/mL of MA5-45419 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 230 kDa. No cross-reactivity against other Nav channels.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarities, including two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC isoforms (α, β, γ) are found in kidney, lung, and colon and are essential for sodium and fluid balance. They also mediate aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
ENaC function is partly regulated through association with CFTR chloride channels. Gain-of-function mutations in β- or γ-ENaC can cause Liddle’s syndrome (hypertension), while loss-of-function mutations in α- or β-ENaC cause pseudohypoaldosteronism type 1 (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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