Thermo Fisher Scientific ALK Monoclonal Antibody (OTI7D6), TrueMAB
인간 ALK 단백질을 인식하는 마우스 단클론 항체로, WB에서 1:2,000 희석 비율로 검증됨. 동결건조 형태로 제공되며, PBS 버퍼와 트레할로스를 포함. 뇌 발달 연구 및 ALK 관련 종양 연구용으로 적합. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
The most common genetic alteration is chromosomal rearrangement that fuses the ALK gene (chromosome 2) with the nucleophosmin (NPM) gene (chromosome 5), forming the oncogenic NPM-ALK fusion gene.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK. It plays a critical role in neuronal development and signaling.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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