Thermo Fisher Scientific ALK Monoclonal Antibody (OTI2B3), TrueMAB
인간 ALK 단백질(aa 1300-1620)을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 뇌 발달 및 종양 관련 ALK 연구용에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements often lead to fusion genes such as NPM-ALK, which are oncogenic.
ALK is a receptor tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It plays a key role in neuronal development and signaling in the nervous system.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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